Cadherin



Cadherins (CDH) are calcium-dependent adhesion proteins. They contain extracellular CDH repeats (EC1-EC5) which bind calcium ions. They are encoded by numerous genes numbered CDH1-CDH23. Some names of CDH indicate their locations: E-CDH (epithelial tissue), VE-CDH (vascular epithelial), T-CDH bound to membrane, N-CDH (neurons). The CDH superfamily contains protocadhedrins (Prot-CDH), desmogleins (Des-CDH) and more. The images at the left and at the right correspond to one representative Cadherin, i.e. the crystal structure of Cadherin (1q1p). Calcium ions is shown as a space filling objects.

3D Structures of Cadherin
Update June 2011

CDH encoded by CDH1
1q1p – mCDH1 - mouse

3q2v – mCDH1 ectodomain

3qrb – mCDH1+2

CDH encoded by CDH5
2koh – mCDH5+PAR3-PDZ3

CDH encoded by CDH6
3lnd – mCDH6 EC12 (mutant)

CDH encoded by CDH8
1zxk – mCDH8 EC1

2a62 - mCDH8 EC1+EC2+EC3

CDH encoded by CDH11
2a4c, 2a4e – mCDH11 EC1

CDH encoded by CDH20
1zvn – cCDH20 EC1 – chicken

CDH encoded by CDH23
3mvs, 2whv – mCDH23 N-terminal

2kbr – hCDH23 peptide+harmonin – NMR - human

2kbs - hCDH23 C-terminal peptide+harmonin PDZ2 – NMR

2wbx – mCDH23 EC1

2wcp - mCDH23 EC2

2wd0 - mCDH23 EC1+EC2 (mutant)

C-CDH “classical”
1l3w – XlC-CDH ectodomain - Xenopus laevis

1q5b, 1q5c, 1q55, 1q5a – C-CDH model into desmosome – electron tomography

E-CDH epithelial
1ff5 – mE-CDH double domain

1edh - mE-CDH EC1+EC2+Ca

3q2l, 3q2n - mE-CDH EC1+EC2 (mutant)

1suh – mE-CDH N-terminal - NMR

3l6x, 3l6y, 1i7x, 1i7w – mE-CDH+catenin

3lne, 3lnf, 3lng, 3lnh, 3lni – mE-CDH EC12 (mutant)

2qvf – mE-CDH1 CDH2

3ifq – hE-CDH EC1+EC2+EC3

2o72 - hE-CDH EC1+EC2

3ff7, 3ff8 - hE-CDH EC1+EC2+EC3+NK cell receptor

2omt, 2omu, 2omx, 2omz, 2omv, 2omw, 2omy – hE-CDH EC1+internalin (mutant)

1o6s – E-CDH N-terminal+internalin – Listeria monocytogenes

T-CDH membrane bound
3k5r – mT-CDH EC1+EC2

3k5s - cT-CDH EC1+EC2

3k6d - XlT-CDH EC1

3k6f - mT-CDH EC1

3k6i - cT-CDH EC1

2v37 – hT-CDH N-terminal - NMR

N-CDH neuronal
1nch, 1nci – mN-CDH

1ncg – mN-CDH (mutant)

2qvi – mN-CDH EC12

1ncj – mN-CDH two domains

3q2w – mN-CDH ectodomain

1op4 - mN-CDH prodomain - NMR

VE-CDH vascular epithelial
3ppe – cVE-CDH EC1+EC2

Protocadherin
2yst – hProt-CDH7 EC3 – NMR

2ee0 - hProt-CDH9 Ca domain – NMR

1wyj - mProt-CDH β 14 - NMR

Desmoglein
2yqg – hDes-CDH EC1